Clinical Study Shows Sabinsa’s Hair Serum Formulation Can Reduce Hair Loss
Led by researchers in India and the United States, the hair serum containing amla extract, freeze-dried coconut water, selenium, sandalwood odorant and coconut shell extract peanut, has been shown to be a safe and effective alternative for managing thinning hair and inducing hair growth.
Posted in the Clinical, cosmetic and experimental dermatologyJournal, the study was funded by Sami Labs Limited and Sabinsa Corporation.
One of the study’s authors, Shaheen Majeed, who is also the chairman of Sabinsa, said: “The effects of hair loss can have emotional consequences. Although herbs and more recently herbal extracts have been used in hair care, this combination of ingredients provides synergistic activity, as each has a different mechanism to protect and nourish hair follicles..”
Majeed said this is the company’s first human clinical trial of the hair serum formulation.
The hair serum formulation is currently licensed to Johara Cosmetics, a skincare line under Sabinsa and Sami Group, but Sabinsa plans to license it to customers around the world, under the AMIFERA brand soon.
The open-label study recruited 42 healthy participants with self-perceived hair loss. The subjects were between the ages of 25 and 45 and had hair loss severity of grades three to six on a 10-point MSCR photonumerical scale.
Participants were instructed to do a two-week washout period, where they were given a neutral shampoo and instructed not to use more than three times per week.
After two weeks, baseline assessments were performed (day 0) and subjects received the hair serum.
The males were instructed to use 2ml and the females 3.5ml once a day at night dividing the hair into parts like a leave in serum.
The study period was three months and participants were required to continue using the neutral shampoo.
TrichoScan was used to measure hair growth rate and hair density. Hair thinning and reduction in hair loss were assessed by dermatologists and a self-assessment questionnaire.
Dermatologists have used the hair comb test and the hair pull test to assess hair thinning and reduction in hair loss. The hair pull test determines how well the hair is anchored to the hair papilla.
The hair serum contains amla extract (Saberry), freeze-dried coconut water (Cococin) and selenium, a micronutrient [PeptiSeLect] (γ-L-Glutamyl-L-selenomethionine), sandalwood and peanut shell extract, supplied by Sabinsa.
Strong hair, less fall
The results revealed that the average rate of hair density improved significantly by 171.35 ± 21.9 per cm2 at 185.01 ± 20.57 per cm2after 90 days. Improvements were observed from the 30th day.
Hair growth rate improved significantly at days 30, 60 and 90 compared to baseline.
The hair pull test significantly reduced the average number of hairs removed per pull from 2.27 to 1.33 (41.4%) at the end of the study compared to baseline. Changes were noticed as early as day 30.
Hair loss with and without bulb was significantly less at days 60 and 90 compared to baseline. The reduction in hair loss with bulb was 57.53% and without bulb 81.60% at the end of the study.
Majeed explained that non-bulb hair loss is the breaking of the hair through the middle, leaving the root intact. “When a bulb is present at the end of a hair strand, it means that the hair has been lost closer to the root. This is indicative of a hair in the telogen phase. This is also normal because hair loss occurs at the end of the telogen phase.
“You may also find more hair loss with bulbs when hair enters a telogen phase prematurely, with loss of active growth, which can lead to diffuse thinning of hair known as telogen effluvium..”
The study also observed that hair thinning was significantly improved at day 60 (7.03%) and day 90 (17.55%) compared to baseline.
The hair serum contained ingredients that provided therapeutic benefits to prevent hair loss and promote hair growth, yet it is gentle on the scalp and free of parabens, formaldehyde and synthetic dyes.
None of the subjects experienced any adverse effects including erythema, allergic reactions, folliculitis, sebum, burning and boils on the scalp.
Amla extract, also known as Indian gooseberry, is extracted from the fruits of the plant Emblica officinalis. It has been shown to stimulate hair growth and make hair softer and shinier.
Coconut is known to condition hair, prevent split ends, reduce frizz, control flaky scalp and dandruff.
Peanut shell extract prevents itching and allergies, while selenopeptide helps hair growth and prevents hair loss.
Sandalwood has been studied in previous research for its reduction in hair loss and promotion of hair growth properties.
The results of this study showed that application of the hair serum formulation to healthy male and female volunteers with moderate hair loss for three months was safe and effective.
Hair loss is a common and stressful symptom, disrupting an individual’s quality of life.
Majeed said that since the hair serum was used on people with moderate hair loss (rank 6 on the 10-point photonumerical MSCR scale), the results were encouraging and the researchers felt the product could benefit people. suffering from severe hair loss.
“We would like to add that hair loss can be due to several reasons. Lack of proper nutrients in diet, medications, medical conditions such as PCOD, hypothyroidism and of course genetic predisposition. In many cases, nutritional supplements can be helpful with this type of hair serum application..”
Majeed said the limitations of this study were inherent in its open-label design. “To limit this bias, we used instruments (Trichoscan and VISIA CR (VISIA CR Imaging) to understand hair density, volume and other parameters. We may conduct larger studies in the future.”
He added that a larger sample size, longer duration and broader population range in a comparative study design could validate his clinical study.
Source: Clinical, Cosmetic and Experimental Dermatology, Dove Press
“Clinical study to evaluate the efficacy and safety of a hair serum product in healthy male and female adult volunteers with hair loss”
Authors: Muhammad Majeed, Shaheen Majeed, et al.